Brochures

Use stability profiling to build more effective gene therapy vectors with Prometheus Panta

Issue link: https://resources.nanotempertech.com/i/1451526

Contents of this Issue

Navigation

Page 4 of 8

Be efficient with simultaneous measurements — get more info from less sample For the first time, combine 4 technologies in a single experiment, along an entire thermal ramp. See how changes in your vector's profile affect downstream properties such as infectivity and potency of your viral vectors. Serotype your vectors and optimize their conformational stability using their intrinsic fluorescence ratio from nano- Differential Scanning Fluorimetry (nanoDSF). Monitor the formation of large aggregates with Backreflection technology, which informs you about the turbidity of your prep. Get disassembly information from changes in your vector's cumulant radius size with Dynamic Light Scattering (DLS). Look for subtle scattering changes that relate to genetic material release with Static Light Scattering (SLS). AAV2, empty vector in PBS AAV8, empty vector in PBS AAV9, empty vector in PBS

Articles in this issue

view archives of Brochures - Use stability profiling to build more effective gene therapy vectors with Prometheus Panta