What DLS tells
you about your
biologics
4
DLS assesses the biophysical characteristics of your
biologics, which will tell you about size, stability, purity
and much more. You can learn whether your sample is
folded or denatured, oligomerized or aggregated, and
how many different species are present in the sample.
You can look at the effect of a mutation or of conjugating
something to your sample, or whether your biologic binds
the drug or target. In this next section we look at how the
different DLS parameters tell you about your biologic.
We start with size and what that data tells you about your
sample quality. A er a larger discussion of sample quality
we explore what DLS data reveals about the stability of
your sample and what it tells you about self-interaction.
There is a lot of information to glean from DLS data. Let's
take a look.
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