As a scientist working in PROTACs, you're tasked with the
most challenging targets — that aim to address intractable
diseases such as cancer, Alzheimer's, or Parkinson's
disease.
Despite the impressive promise of PROTACs to address
these targets, you still have to overcome many hurdles in
the development of PROTACs, such as their poor cellular
permeability due to their high molecular weight and
the difficulty when characterizing binary and ternary
complexes.
Therefore, the key to robust, rational design of PROTACs
is to understand their structure-activity relationship
throughout the degradation pathway, so you use the right
tools to confirm your final product is leading to complete
protein degradation.
Here are four important questions to ask yourself in your
PROTAC development process to ensure you're building an
effective protein degrader — and using the right tools at
each step.
