Issue link: https://resources.nanotempertech.com/i/1291774
Monitor essential attributes throughout your biologics workflow Your candidate molecules go through a long and complicated journey on their way to becoming a final product. Using the same instrument throughout this process ensures there's consistency when you need to compare conformational and colloidal stability data across teams and sites. Start multi-parameter characterization early on when candidate molecules are being considered, engineered, or modified, and then continue comparing throughout formulation, production, and validation with Prometheus Panta. Developability Determine aggregation propensity Get self and non-specific interactions Characterize conformational (thermal) stability Downstream process development Characterize conformational (thermal) stability and determine aggregation propensity and size distribution during scale-up and optimization of processes Antibody engineering & stability enhancement Determine aggregation propensity Get self and non-specific interactions Characterize conformational (thermal) stability Comparability assessment Characterize conformational (thermal) stability including accelerated stress conditions spanning a broad concentration range Determine particle size distribution Investigational new drug (IND) & New drug application (NDA) Determine thermal stability and particle sizing on reconstitution/ dilution/admixing at initial and final time points Get thermal stability and particle sizing from forced degradation and photostability studies Pre-formulation & formulation Characterize conformational (thermal) stability Determine aggregation propensity Perform buffer and excipient screening and compatibility with melting scans with particle sizing, size distribution, and aggregation propensity