NanoTemper Advanced features in the new Monolith

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What's new? Why is this better? New Design d Higher throughput Monolith now has 24 capillaries instead of 16 Allows for screening up to 6 different buffers, shortening assay optimization time For expert users, get two 12-point K d in Expert mode, either with duplicates or analyze two different ligands Redesigned capillary tray Deeper notches Capillary spacing matches standard 384-well plate format Capillaries sit more securely in the tray If you're used to placing capillaries loaded with sample individually into the tray, you can now place them empty individually, cover them with magnetic lid, and then load samples simultaneously by dipping the capillaries into the dilutions prepared in a 384-well plate Capillary tray can move faster during capillary scans Capillary scans take less time Measurement times are reduced to 10 minutes or less per K d Larger touchscreen with real-time information and short tutorial See MST power, excitation power, temperature, and real-time MST traces On-screen tutorial shows how to operate the new Monolith Know what's going on with your assay at all times, even from far away Get to know your new instrument in no time Better temperature control The thermal elements are now in direct contact with the capillaries Get more homogeneous fluorescent intensity and Fnorm signals which result in higher S/N ratios for some of your challenging targets Monolith Pico Monolith Pico models can now efficiently measure at both ends of the sensitivity range You can now turn the pico mode on and off to select the sensitivity range that fits your interaction Combined LabelFree and RED detecor Monolith and Monolith Pico are now available with the combination of a RED and a LabelFree detector Having both detectors in one instrument provides the highest versatility and flexibility of all Monolith instruments New So ware Capabilities Updated binding check module Buffer screen of up to 6 buffer conditions added to the binding check module Screen up to 6 different buffer conditions in duplicates and with no-ligand controls in the same run MO.Control 2 updates Auto-update Make sure you are running the latest version by enabling this optional feature (requires to be online) New way to list capillaries and their corresponding MST traces Capillaries and their corresponding MST traces are always listed from low to high ligand concentration from right to le The capillary order is now consistent in all instances of the so ware New Assay Development Tools Buffer Exploration Kit 96-well plate loaded with ready-to-use buffers commonly used in MST assays You don't have to pre-mix them yourself which makes assay optimization less time consuming Protein Labeling Assistant An online interactive tool that helps you choose the best labeling strategy for your target protein Feel confident you are getting the best labeling recommendations for your target and instrument optics Advanced features in the new Monolith I want to learn more about the new Monolith Familiar with Monolith NT.115 and want to know the difference? Monolith has a new look and some great new features like better temperature control, a larger touchscreen, and improved assay development tools to get your assay ready sooner.

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