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NanoTemper Neurodegenerative Diseases Brochure

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Easily characterize the molecular mechanisms of neurodegenerative diseases When studying neurodegenerative diseases you probably encounter technical challenges that come from working with proteins that aggregate or are intrinsically disordered. With NanoTemper's tools you overcome these difficulties and start getting results. At Celon Pharma, we work with target proteins that lack enzymatic activity, making screening for potential drug candidates very challenging. Monolith provides us a new approach that brings a fast and reliable solution for the screening of small molecule-protein and protein-protein interactions. The benefits are multiple: reduced costs due to low protein consumption, time saving for screening campaigns due to fast run times, and easy setup so everyone in the lab can use it. Mikolaj Matloka Team Leader Neuropsychiatry Research Group Celon Pharma nanotempertech.com Gain insights into protein aggregation Analyze molecular interactions with co-factors that lead to protein aggregation or with molecules that stabilize the monomeric state and prevent aggregation Screen for small molecules Find protein-protein interaction inhibitors even for strong, picomolar affinity interactions Study disordered proteins Determine their binding affinities in solution even from cell lysates, membrane fragments, or cerebrospinal fluid Characterize complex systems Mix your protein of interest with other molecules besides the ligand — cofactors, secondary ligands or multivalent scaffolds — to study interactions in more complex systems Get lots of data from a little sample Use only a few microliters of your precious sample to get insights about molecular interactions or thermal unfolding

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