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Going small to win big: Fragment-based screening in drug discovery

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Contents Strengths of fragment-based screening for drug discovery The future of fragment-based drug discovery Biophysics provides the best tools for finding hits Why is fragment-based screening so popular? Top biophysical methods for fragment-based screenings a b c d e Nuclear Magnetic Resonance Temperature-Related Intensity Change Surface Plasmon Resonance X-ray Crystallography Thermal Shift Assay 1 5 4 2 3

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