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The researcher’s guide to measuring binding affinity and why it matters

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15 Your funding source for new equipment will vary depending on if you are in academia or industry. At a university, you can apply for a grant to fund the purchase. Also, you may receive support from external sources that are interested in funding your research. These external sources include foundations, private donations, crowdsourcing platforms such as GoFundMe, or collaborations with other groups that have similar interests. To make the purchase more affordable, consider asking for support from other groups at your institution who share your interests and have extra funding. Or, consider purchasing an entry-level instrument and plan to upgrade it at a later time. As with any other big purchases, once the financing is in place, the rest of the process is relatively straightforward. Most technologies will require some form of installation, implementation, and training. Aside from occasional support and maintenance, your new instrument is ready to become an invaluable part of your workflow, providing valuable data that supports your research. TOTAL COST OF INVESTMENT Budgeting properly for a new instrument means looking at more than just the price tag––there are other costs to consider. Here is everything to be aware of when thinking about the total cost of your investment: • Purchasing costs – the sticker price of the new system • Installation costs – how much it costs to have the instrument set up by the vendor • Running costs – how much it costs to run the system in terms of consumables and energy • Service and maintenance costs – how much you will get charged for repairs or regularly scheduled maintenance, and how that impacts lab downtime • Support costs – how much it will cost to get technical support for the so ware or scientific support for your applications • Additional so ware upgrades – what you can expect to pay for major so ware upgrades

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