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Several vendors offer technologies that characterize
protein stability, and information about their product
offerings can mostly be found on the companies'
websites or in sales collateral such as catalogs,
brochures, and videos.
Browsing a product's specifications and features should
help answer key questions about the technology, such
as whether or not the instrument and so ware are user-
friendly, the size of the footprint, and what consumables
are required for its use.
Although this information will certainly help, it may not
answer all of your questions. Therefore, you may need to
contact the vendor. Before you do that, you should have
a list of questions prepared that will help determine if the
instrument is right for your lab. These might include:
• How easy is it to run the instrument or set up an
experiment?
• How long does it take to run an experiment?
• Are the consumables complicated to use, and what
do they cost?
VENDORS (ALPHA ORDER)
Malvern Instruments
www.malvern.com
Malvern's PEAQ-DSC instruments enable DSC
NanoTemper Technologies
nanotempertech.com
NanoTemper offers Prometheus, a series of systems
that uses a specialized, label-free version of DSF to
characterize thermal unfolding, chemical denaturation,
and aggregation.
TA Instruments
www.tainstruments.com
TA Instruments makes differential scanning calorimeters
Jasco
jascoinc.com/
Provider of circular dichroism instruments.
Unchained Labs
www.unchainedlabs.com
UNcle is a multimode reader platform that measures a
number of stability parameters
Wyatt Instruments
www.wyatt.com
Wyatt's instruments employ dynamic and
electrophoretic light scattering technology
Note: This list does not include the many vendors that sell SYPRO
orange dye for DSF experiments or those that provide PCR machines
certified for use in thermofluor experiments.
How do I
evaluate vendors?
