Figure 1: Biosimilar profiling using nanoDSF. (A) Raw nanoDSF data of the thermal unfolding of the originator (red) and 17
biosimilar candidates. Measurements were carried out in triplicates. Changes in the F350/F330 fluorescence ratio are shown.
(B) Comparison of T
m
values of the samples. Note that the reference molecule and sample #11 do not show a 2
nd
unfolding
transition in the F350/F330 ratio.
