Where Prometheus is
making a difference
Drug discovery & development
Use every time stability needs to be
characterized and monitored to rank
molecule candidates
Structural biology
Maximize protein solubility and
stability before crystallization to
dramatically increase its probability of
crystallization
Gene therapy
Differentiate viral vectors serotypes
during development and manufacturing
based on their thermal stability profiles
Biologics discovery and development
Evaluate target-ligand complexes before
affinity-based screening
Developability assessment
Pre-formulation and formulation
Production & downstream process
development
Comparability studies
Thermal shi assays
Screen compounds during drug
development for shi s in thermal
unfolding to eliminate compounds that
decrease stability
Protein expression & purification
Monitor the stability of recombinant
proteins during selection of expression
clones and chromatographic isolation and
purification
Chromatography
Monitor stability of recombinant proteins
during chromatographic isolation and
purification
Scientific areas Workflows Techniques
